The Messier Catalog: Charles Messier was interested in cataloging comets. Frustrated with his hunt, the compiled a large list of non-comet objects that he saw in the sky. This became one of the top referenced list of astronomical objects. These objects are given Messier numbers (M1, M2, M3…). So a list entirely of objects that the author had no interest in ended up being one of the top referenced lists ever.
It is possible to create a human being that is not aware of the concept of vision. See the book “The Man Who Mistook His Wife for a Hat and Other Clinical Tales” by Oliver Sacks.
Proprioception: This is our awareness of our limbs’ positions. A few case studies caused by the loss of proprioception are mentioned in the book above by Oliver Sacks.